Endocrine Abstracts

Neonatal Diabetes Mellitus (NDM) occurs in the neonatal period and has a very high burden of morbidity and mortality. The incidence is approximately 1:100,000 but reports range from between 1 in 25,000 to 1:500,000 live births. A genetic cause can be found in over 80% of cases. At present, patients with NDM are unrecognised as being seriously ill until hyperglycaemia is at a life-threatening level. An effective method for measuring blood glucose concentrations from Guthrie car...

The mechanism by which the thionamide antithyroid drugs produce long-term remission of Graves’ hyperthyroidism is unknown. We wished to explore the hypothesis that methimazole (MMI) could induce a structural change in thyroid peroxidase (TPO), such that its major (immunodominant) epitope(s) was no longer recognised by circulating anti-TPO antibodies.An enzymatically active membrane preparation of a CHO cell-line stably transfected with human TPO was...